SLENTROL is indicated for the management of obesity in dogs. SLENTROL (dirlotapide) is a solution formulated at a concentration of 5 mg/mL of dirlotapide for oral administration of dogs.
What is Slentrol Oral Solution?
Slentrol oral prescription medication for weight management in obese dogs helps reduce fat absorption in the body. It also works in the intestine to help control appetite through its effect on fat absorption.
Who is Slentrol Oral Solution for?
Dogs
Why use Slentrol Oral Solution?
- Helps manage obesity
- Contains dirlotapide to control appetite
- Helps reduce the body's fat absorption
- Manage canine obesity
- Surpress apetite
- Decrease food intake
How does Slentrol Oral Solution work?
Slentrol helps reduce fat absorption in the body. It also works in the intestine to help control appetite through its effect on fat absorption.
Zoetis
Dirlotapide
How is Slentrol Oral Solution sold?
SLENTROL is available in 20, 50 and 150 mL bottles containing 5 mg/mL of dirlotapide in solution.
What are the side effects of Slentrol Oral Solution?
Almost 1 in 4 of dogs placed on SLENTROL therapy experienced occasional episodes of vomiting and diarrhea. In most cases these episodes lasted for one or two days. The vomiting occurred most often during the first month of treatment or within a week of a dose increase. If vomiting does occur it is recommended to continue dosing at the same dose volume, however, the time of day or method of administration (with or without food) may be changed. If vomiting is severe or lasts longer than 2 days, consult your veterinarian immediately and have your dog evaluated.
What special precautions are there?
Safety in breeding, pregnant, or lactating dogs has not been established. Caution should be taken when considering any weight loss program in growing dogs, including treatment with SLENTROL.
SLENTROL has not been evaluated in dogs less than 1 year of age.
If overdose contact your vet immediately.
How can I store Slentrol Oral Solution?
Store in original container at room temperature 15° to 30° C (59° to 86° F).
Obesity requires serious treatment. While exercise and diet remain important, they are not always enough. The need for a proven and dependable medication that can help veterinarians manage obesity safely and effectively has long been evident. Treatment with SLENTROL provides steady, sustained weight loss over time, during which owners can develop new and fundamentally better feeding behaviors and exercise regimens for their dogs. Because Slentrol induces weight loss and helps with weight management, your dog will be less at risk for diseases like arthritis and heart disease that are associated with obesity.
SLENTROL is an oral solution administered once daily with an easy-to-use calibrated oral dosing syringe. SLENTROL can be given directly into the dog’s mouth, on a treat, or with a small amount of food. SLENTROL is not a cure for obesity, but as part of an overall weight-management program that includes appropriate diet and exercise, the medication can help obese dogs benefit from weight loss. And that can make a difference for pets and their owners.
Slentrol may be given directly into the dog's mouth or on a small amount of food. The dose of Slentrol must be specifically calculated each month by your veterinarian based on the amount of weight the dog lost during the previous month.
The dose should not exceed a maximum daily dose of 0.2 mL/kg (0.09 mL/lb), based on the dog’s current body weight, during any part of treatment.
SLENTROL should not be used in cats, dogs receiving long-term corticosteroid therapy, or in dogs with liver disease. The most common side effect is vomiting. In addition, dogs may experience diarrhea, lethargy, or anorexia. The client should be made aware that if any of these signs persist for more than 2 days the dog should be re-evaluated. SLENTROL is not for use in humans under any circumstances.
SLENTROL (dirlotapide) is a solution formulated at a concentration of 5 mg/mL of dirlotapide for oral administration to dogs. Dirlotapide is a selective microsomal triglyceride transfer protein inhibitor that blocks the assembly and release of lipoprotein particles into the bloodstream (via the lymphatic system) in dogs.1 The empirical formula is C40H33F3N4O3 and the molecular weight is 674.73. The chemical name is (S)-N-{2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4’-(trifluoromethyl)[1,1’-biphenyl]-2-carboxamido]-1H-indole-2-carboxamide.
