Estrumate (Cloprostenol Sodium) is for intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estrumate (Cloprostenol Sodium) can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function. Available in 10 dose/20 ml vial or 50 dose/100 ml vial.
What is Estrumate (Cloprostenol Sodium)?
Estrumate (Cloprostenol Sodium) is for intramuscular use to induce luteolysis in beef and dairy cattle. The luteolytic action of Estrumate (Cloprostenol Sodium) can be utilized to manipulate the estrous cycle to better fit certain management practices, to terminate pregnancies resulting from mismatings, and to treat certain conditions associated with prolonged luteal function.
Who is Estrumate (Cloprostenol Sodium) for?
Cattle (Beef and Dairy)
Why use Estrumate (Cloprostenol Sodium)?
-Can be utilized to manipulate the estrous cycle in beef and dairy cattle
-Treats certain conditions associated with prolonged luteal function
How does Estrumate (Cloprostenol Sodium) work?
Estrumate (Cloprostenol Sodium) causes functional and morphological regression of the corpus luteum (luteolysis) in cattle. In normal, nonpregnant cycling animals, this effect on the life span of the corpus luteum usually results in estrus 2 to 5 days after treatment. In animals with prolonged luteal function (pyometra, mummified fetus, and luteal cysts), the induced luteolysis usually results in resolution of the condition and return to cyclicity. Pregnant animals may abort depending on the stage of gestation.
Merck Animal Health
(Cloprostenol Sodium)
Prostaglandin Analogue for Cattle
Equivalent to 250 mcg cloprostenol/mL
How is Estrumate (Cloprostenol Sodium) sold?
10 dose / 20 ml vial or 50 dose / 100 ml vial
What are the side effects of Estrumate (Cloprostenol Sodium)?
Contraindications : Estrumate should not be administered to a pregnant animal whose calf is not to be aborted. SAFETY AND TOXICITY: At 50 and 100 times the recommended dose, mild side effects may be detected in some cattle. These include increased uneasiness, slight frothing, and milk let-down.
What special precautions are there?
Warnings : For veterinary use only. * Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Estrumate is readily absorbed through the skin and may cause abortion and/or bronchospasms; direct contact with the skin should therefore be avoided. Accidental spillage on the skin should be washed off immediately with soap and water.
Precautions : There is no effect on fertility following the single or double dosage regimen when breeding occurs at induced estrus or at 72 and 96 hours post treatment. Conception rates may be lower than expected in those fixed time breeding programs which omit the second insemination (ie, the insemination at or near 96 hours). This is especially true if a fixed time insemination is used following a single Estrumate injection. As with all parenteral products, careful aseptic techniques should be employed to decrease the possibility of post injection bacterial infection. Antibiotic therapy should be employed at the first sign of infection.
Contact your nearest emergency animal hospital. You may also contact Merck Animal Health Pharmacovigilance: Livestock Technical Services, 800-211-3573
How can I store Estrumate (Cloprostenol Sodium)?
STORAGE CONDITIONS :
1. Protect from light.
2. Store in container.
3. Store at controlled room temperature 59°-86° F. (15°-30° C).
4. Use within 28 days of first use.
Use as directed by your Veterinarian
Dosage and Administration :
Two mL of Estrumate (500 mcg of cloprostenol) should be administered by INTRAMUSCULAR INJECTION for all indications in both beef and dairy cattle.
100-mL: Do not puncture stopper more than 12 times.
(Cloprostenol Sodium)
Prostaglandin Analogue for Cattle
Equivalent to 250 mcg cloprostenol/mL
